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  • Title: [Embryonal hematopoiesis in the intact human liver and in its organ culture].
    Author: Makartseva TM, Nastenko EP.
    Journal: Arkh Anat Gistol Embriol; 1983 Jul; 85(7):62-6. PubMed ID: 6625905.
    Abstract:
    Hepatic tissues in 58 human embryos, 5-12 week-old have been investigated. At that time hemopoiesis is mainly presented by erythropoiesis. Ultrastructure of the hepatic parenchymal cells and that of the hemopoietic cellular elements have been studied. The cultural system used makes it possible to maintain hemopoiesis in the explants for 3.5 weeks. Under the conditions of cultivation in the organic culture, certain changes in architectonics of the explants are observed. As the time of the cultivation increases, the ultrastructure of the hepatic parenchymal cells, which make the hemopoiesis-inducing microenvironment, undergo further changes. A gradual substitution of erythropoiesis for granulomonocytopoiesis takes place.
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