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  • Title: [Response of isolated coronary artery segments to serotonin in the presence of a flavinoid, indomethacin and acetylsalicylate].
    Author: Bettini V, Gamba G, Legrenzi E, Libardoni C, Mayellaro F.
    Journal: Boll Soc Ital Biol Sper; 1983 Aug 30; 59(8):1064-9. PubMed ID: 6626342.
    Abstract:
    The aim of this work is to study the mechanism by which 4-metilesculetin (4-Me) cause the relaxation or inhibit the serotonin induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and serotonin induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.
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