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  • Title: [Circadian rhythm of ventilatory parameters of intrinsic asthma in clinical remission].
    Author: De Benedetto F, Cervone M, De Blasio E, De Matthaeis G, Fuciarelli R, Luciano A, Sborgia M, Sensi S.
    Journal: Boll Soc Ital Biol Sper; 1983 Aug 30; 59(8):1082-5. PubMed ID: 6626343.
    Abstract:
    In six subjects with intrinsic asthma in clinical remission, time-structure of ventilatory parameters has been evaluated in order to evaluate: 1) which indexes present statistically significant circadian fluctuations; 2) if phase-shifts occur in comparison with normal subjects. After a period of synchronization of 7 days (L/D: 07.30-23.00; meal timing at 08.00, 13.00 and 20.30) all subjects have been studied by spirometry, flow-volume loop and Raw determination 6 times in a 24-hr period at constant intervals of 4 hrs. The results have been evaluated by macroscopic and microscopic analysis statistical significant fluctuations have been shown in these functional indexes: MEF50, Raw, SRaw, SGaw, FRC and RV; no phase-shifts occurred in comparison with normal subjects. On the contrary a circadian rhythm has not been shown in FVC, FEV1, and PEF. Therefore only the effort-independent test should be used to study correctly the bronchial tone.
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