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  • Title: Cadmium and thallous ion permeabilities through lipid bilayer membranes.
    Author: Gutknecht J.
    Journal: Biochim Biophys Acta; 1983 Oct 26; 735(1):185-8. PubMed ID: 6626547.
    Abstract:
    Cadmium (Cd2+) and thallous ion (Tl+) permeabilities were measured in planar (Mueller-Rudin) lipid bilayer membranes made from diphytanoylphosphatidylcholine in decane. Permeabilities of the electroneutral Cl- complexes, measured with tracers (109Cd and 204Tl), were about 10(-8) cm X s-1 for CdCl2 and 10(-6) cm X s-1 for TlCl. Electrical conductance measurements showed that permeabilities to Cd2+ and Tl+ were approx. 10(-11) cm X s-1, similar to the Na+ permeability. The low permeabilities to both Cd2+ and CdCl2 are consistent with biological studies which suggest that Cd transport and toxicity are protein mediated and correlated with Cd2+, not CdCl2, concentration. However, the low bilayer permeability to Tl+ raises questions about recent reports that Tl+ is a lipid permeable cation in biological membranes and liposomes. An alternative explanation for the lipid permeable behavior of Tl+ is presented, based on the diffusion of TlCl and other complexes of Tl+ with inorganic and organic anions.
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