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  • Title: [Use of the antioxidant ionol to prevent damage to the heart from prolonged administration of antitubercular preparations].
    Author: Iakovleva TA, Dolgikh VT, Poluéktov LV.
    Journal: Biull Eksp Biol Med; 1983 Oct; 96(10):59-62. PubMed ID: 6626733.
    Abstract:
    Prolonged administration of isoniazid, protionamide and rifampicin to white rats is accompanied by marked depression of myocardial contractile function determined by the distress of membranous mechanisms of calcium transport because of excessive activation of lipid peroxidation in cardiomyocyte biomembranes. Administration of ionol coupled with antituberculous drugs prevents their cardiotoxic effects.
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