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  • Title: [Effect of sodium thiosulfate on viable areas of the pancreas in experimental pancreatitis].
    Author: Kanaian AS, Gabrielian NA, Gevorkian GA.
    Journal: Biull Eksp Biol Med; 1983 Oct; 96(10):68-70. PubMed ID: 6626734.
    Abstract:
    Experimental pancreatitis in white rats is marked by stromal edema, dystrophic changes of acinar cells, with intracellular edema in an intact part of the pancreas. Subsequently the acinar cells undergo intracellular regeneration and hypertrophy, which is accompanied by intensive incorporation of 14C-leucin into glandular proteins. Sodium thiosulfate prevents the development of stromal edema and intracellular edema of the acinar cells and retards the development of acinar cell hypertrophy. The drug produces an inhibitory action on 14C-leucin incorporation into pancreatic proteins.
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