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  • Title: Prevalence and diagnosis of laboratory animal allergy.
    Author: Beeson MF, Dewdney JM, Edwards RG, Lee D, Orr RG.
    Journal: Clin Allergy; 1983 Sep; 13(5):433-42. PubMed ID: 6627621.
    Abstract:
    A survey of the prevalence of laboratory animal allergy to rats, mice, guinea pigs and rabbits among sixty-nine animal workers and 308 other subjects on a pharmaceutical research site revealed a 22% prevalence of laboratory animal allergy among the animal workers. The overall prevalence of atopy was 67% in persons with allergy to laboratory animals. This was significantly greater than the 31% prevalence in other animal workers. Skin-prick tests and specific IgG and IgE assays to urinary protein extracts strongly correlated with the occurrence of laboratory-animal allergy and would appear to have diagnostic value. However, a number of clinically diagnosed laboratory-animal-allergy subjects gave no evidence of immunological response to the urinary allergens and wider diagnoses may have to be applied in these cases.
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