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  • Title: Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome.
    Author: Miller LJ, Bartholomew LG, Dozois RR, Dahlin DC.
    Journal: Dig Dis Sci; 1983 Nov; 28(11):1047-51. PubMed ID: 6628153.
    Abstract:
    The malignant potential of the hamartomatous polyps in Peutz-Jeghers syndrome has been debated. Although this is a very rare event, these polyps can undergo carcinomatous transformation, as demonstrated by this report of a 37-year-old man with well-documented Peutz-Jeghers syndrome who developed an invasive grade 2 adenocarcinoma on the surface of a hamartomatous polyp in the rectum.
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