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  • Title: Dantrolene sodium: stimulatory and depressant effects on the contractility of guinea-pig uterus in vitro.
    Author: Conte-Camerino D, Lograno MD, Siro-Brigiani G, Megna G.
    Journal: Eur J Pharmacol; 1983 Sep 02; 92(3-4):291-4. PubMed ID: 6628542.
    Abstract:
    The effects of dantrolene sodium on the spontaneous and oxytocin-induced contraction of guinea-pig uterus were studied in vitro. Dantrolene reversibly increased the spontaneous contraction frequency of guinea-pig uterus. The effect was not dose-related and was not antagonized by atropine, methysergide or indomethacin. Dantrolene dose dependently and reversibly reduced the contractile responses of guinea-pig uterus to oxytocin. The varying effects of dantrolene on the uterus probably involve inhibition of calcium movement at more than one site of the muscle.
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