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  • Title: [Cardiostimulating action of liposome-incorporated noradrenaline during adrenergic-receptor block].
    Author: Dmitrieva AV, Stefanov AV, Boĭko VI, Gurevich MI, Lishko VK.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1983 Aug; 69(8):1023-30. PubMed ID: 6628745.
    Abstract:
    Norepinephrine (NE) contained in liposomes increased myocardial contractility and raised the blood pressure with no bradycardia or arrhythmia. NE exerted this cardiostimulating effect in condition of complete adrenoreceptor blockade. Separate infusion of NE and liposomes restored the sensitivity of the adrenergic structures in adrenergic blockade. Modified effect of liposome-entrapped NE depends on liposome effect upon the cell membrane and on concentration of NE in the blood.
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