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  • Title: Aldehyde dehydrogenase (E.C. 1.2.1.3) in chronic alcoholic liver diseases.
    Author: Nilius R, Zipprich B, Krabbe S.
    Journal: Hepatogastroenterology; 1983 Aug; 30(4):134-6. PubMed ID: 6629303.
    Abstract:
    Acetaldehyde dehydrogenase (ALDH) activity in liver biopsy specimens was considerably reduced in alcoholic cirrhosis (n = 5), elevated in alcoholic fatty liver (n = 11)--probably due to enzyme induction--only slightly elevated in alcoholic hepatitis (n = 6), but unaffected in non-alcoholic liver diseases (n = 23) in comparison with specimens obtained from patients with minimal liver lesions. We will argue as a working hypothesis that alcoholics with induced ALDH activity will mainly develop fatty liver, whereas reduced hepatic ALDH appears to be a reason for elevated acetaldehyde levels followed by additional liver injury and progression at least for alcoholic cirrhosis.
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