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  • Title: Do vitamins prevent neural tube defects (and can we find out ethically)?
    Author: Lipsett MB, Fletcher JC.
    Journal: Hastings Cent Rep; 1983 Aug; 13(4):5-8. PubMed ID: 6629750.
    Abstract:
    Proposals have been made to the National Institute of Child Health and Human Development for a clinical trial to determine the role of vitamin supplements in the prevention of neural tube defects. In view of incomplete British studies suggesting a positive effect, American researchers and ethicists have debated the scientific validity and ethical implications of various research design options. Policy makers are faced with the dilemma that, while a randomized, placebo-controlled study may yield the information required for the establishment of a definitive prevention program, there are ethical problems in withholding apparently safe, inexpensive, and possibly beneficial vitamin supplements from women at risk.
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