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  • Title: Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals.
    Author: Bond WW, Favero MS, Petersen NJ, Ebert JW.
    Journal: J Clin Microbiol; 1983 Sep; 18(3):535-8. PubMed ID: 6630443.
    Abstract:
    In five separate tests, hepatitis B virus in dried human plasma was exposed for 10 min at 20 degrees C to disinfectant chemicals having activity levels ranging from intermediate (e.g., 70% isopropyl alcohol) to high (e.g., 2% aqueous glutaraldehyde at pH 8.6). Five chimpanzees (one animal per disinfectant chemical) received treated material intravenously, and none showed signs of infection after post-inoculation periods of 9 months. Two animals were rechallenged with inoculum treated in the same manner, except that saline was used instead of a disinfectant chemical; both were infected within 4 weeks. Our results showed that hepatitis B virus was not as resistant to disinfectant chemicals as once thought and suggested that chemicals with similar activity levels (intermediate to high) might possibly be used on hepatitis B virus contamination with a margin of safety.
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