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  • Title: Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro.
    Author: Stephens DT, Critchlow LM, Hoskins DD.
    Journal: J Reprod Fertil; 1983 Nov; 69(2):447-52. PubMed ID: 6631812.
    Abstract:
    Low levels of gossypol inhibited motility and anaerobic glycolysis of ejaculated rhesus monkey spermatozoa. Inhibition (50%) of both occurred at a gossypol: sperm ratio of 8 nmol/10(8) spermatozoa, and complete inhibition of both occurred at a ratio of 75 nmol/10(8) spermatozoa. Determination and comparison of the levels of glycolytic intermediates in intact spermatozoa, incubated with and without gossypol, indicated that the only site of glycolytic inhibition was lactate dehydrogenase-X (EC 1 X 1 X 1 X 27). At gossypol: sperm ratios above 6 nmol/10(8) spermatozoa, gossypol also decreased the concentrations of the adenine nucleotides, ATP, ADP and AMP, and this is most probably the basis for its toxic effect on spermatozoa.
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