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  • Title: Blood lipids and antihypertensive drugs. The Oslo study.
    Author: Leren P, Eide I, Foss OP, Helgeland A, Hjermann I, Holme I, Kjeldsen SE, Lund-Larsen PG.
    Journal: J Pharmacol; 1983; 14 Suppl 2():217-20. PubMed ID: 6632918.
    Abstract:
    The treatment of hypertension has failed to achieve a reduction of the incidence of coronary heart disease. Recently, attention has been drawn to the effects of antihypertensive drugs on the metabolism of lipoproteins. Of the beta-blockers only pindolol was lipid neutral while propranolol, atenolol and oxprenolol lowered cholesterol and increased serum triglycerides. Hydrochlorothiazide did not influence blood lipids. Prazosin lowered serum LDL + VLDL cholesterol and total triglycerides. The combination of pindolol + prazosin lowered LDL + VLDL cholesterol and increased triglycerides. Propranolol + prazosin lowered HDL cholesterol, methyldopa + hydrochlorothiazide and hydrochlorothiazide + amiloride had no effect on blood lipids.
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