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  • Title: [Natriuretic effect of haloperidol in dogs].
    Author: Cuche JL, Prinseau J, Baglin A, Guedon J.
    Journal: Nephrologie; 1983; 4(3):103-5. PubMed ID: 6633776.
    Abstract:
    A 0.5 microM/kg/min infusion of haloperidol in the renal artery of 20 sodium-loaded dogs undergoing water diuresis is showed to induce the following net effects: a statistically significant reduction of both clearance of PAH (-18.1 +/- 6.6 ml/min), and glomerular filtration rate (-4.3 +/- 1.5 ml/min), an increase of both fractional excretion of sodium (+ 6.8 +/- 1.1%) and potassium (+ 55.1 +/- 5.5%), a decrease of fractional excretion of phosphate (-5.3 +/- 1.5%), and a lack of change of free water clearance (infused minus controlateral kidney difference).
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