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  • Title: [3H]diazepam binding sites on chick neurons in primary culture.
    Author: Mallorga P, Ebel C, Roth-Schechter BF.
    Journal: Neurosci Lett; 1983 Aug 19; 39(1):45-50. PubMed ID: 6633937.
    Abstract:
    High affinity [3H]diazepam binding sites were identified on neurons prepared from the hemispheres of 8-day-old chick embryos and grown in serum-containing or serum-free medium. Clonazepam (IC50 = 3 nM) was more potent than Ro 5-4864 (IC50 greater than 1000 nM) in displacing [3H]diazepam binding. GABA and pentobarbital, in the presence of chloride ions were able to stimulate [3H]diazepam binding synergistically. These interactions were found to be comparable to those observed in mammalian brain.
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