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  • Title: The effect of medial preoptic-anterior hypothalamic lesions on testosterone plasma levels and testosterone conversion in the hypothalamus of male rats.
    Author: Lupo C, Dessi-Fulgheri F, Musi B, Larsson K.
    Journal: Neurosci Lett; 1983 Sep 09; 39(3):261-5. PubMed ID: 6633956.
    Abstract:
    Male Wistar rats were submitted to bilateral high frequency lesions in the medial preoptic-anterior hypothalamic area or to sham procedure. The behavioral effect of the lesions was observed and plasma testosterone (T) and estradiol (E2) were measured by radioimmunoassay. In vitro metabolism of T was studied in the hypothalamus. Lesions produced a permanent deficit in male sexual behavior, an increase of plasma T and E2, and of hypothalamic T aromatization, and a decrease of T conversion to 5 alpha-dihydrotestosterone (DHT).
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