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  • Title: Steric influence on inhibition of monoamine oxidase forms by 2,3-dichloro-alpha-methylbenzylamine.
    Author: Fuller RW, Hemrick SK.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Apr; 20(1):199-202. PubMed ID: 663404.
    Abstract:
    The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). In contrast, the (-) isomer inhibited phenylethylamine oxidation more than it inhibited serotonin oxidation. These apparently are the first pair of stereoisomers observed to have opposite selectivity as inhibitors of types A and B MAO.
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