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  • Title: des-Tyr1-gamma-endorphin and haloperidol increase pineal gland melatonin levels in rats.
    Author: Gaffori O, Geffard M, van Ree JM.
    Journal: Peptides; 1983; 4(3):393-5. PubMed ID: 6634474.
    Abstract:
    The effect of subcutaneously injected DT gamma E (beta-endorphin, (beta E)2-17) on the pineal melatonin level was compared with that of closely related peptides and the neuroleptic drug haloperidol. As found previously, DT gamma E (3 ng/rat and 300 ng/rat) increased the melatonin levels. Similar doses of DT alpha E (beta E 2-16), DT beta E (beta E 2-31), gamma E (beta E 1-17), alpha E (beta E 1-16) and beta E failed to significantly change the melatonin levels in both the dark and the light phase. Haloperidol in a dose of 300 ng/rat exhibited a similar effect as DT gamma E.
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