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Title: Effect of partially purified B- and T-lymphocyte inhibitory factors on the mitogenic and chemotactic responses. Author: Martin DE, Glick B. Journal: Poult Sci; 1983 Sep; 62(9):1856-9. PubMed ID: 6634612. Abstract: Avian lymphocyte inhibitory factor (LyIF) is produced by thymic (T) and bursal (B) lymphocytes following sensitization of chicks to Mycobacterium tuberculosis. Our previous studies showed that maximum activities for both B- and T-LyIF were within a molecular weight range of 10,000 to 50,000 daltons (LyIF-III). These results led us to question what other functional differences may exist. The chemotactic and mitogenic properties of B- and T-LyIF-III were investigated. Neither B- nor T-LyIF-III had chemotactic properties whereas both lymphokines significantly inhibited the uptake of [3H]-thymidine in the presence of phytohemagglutinin-M. Inhibition of migration by LyIF-III may be a reflection of LyIF-III inhibition of deoxyribonucleic acid synthesis.[Abstract] [Full Text] [Related] [New Search]