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  • Title: Antibodies to purified insulin receptor have insulin-like activity.
    Author: Jacobs S, Chang KJ, Cuatrecasas P.
    Journal: Science; 1978 Jun 16; 200(4347):1283-4. PubMed ID: 663609.
    Abstract:
    Antibodies to insulin receptors purified from rat liver membranes do not complete with [125I]insulin for binding to the insulin receptor but do precipitate solubilized receptors labeled with [125I]insulin. These antibodies have the insulin-like activities of enhancing glucose oxidation and inhibiting epinephrine-induced lipolysis in rat adipocytes. Thus, antibody binds to the receptor at a different site from that to which insulin binds, yet the interaction can initiate an effective biological response. These results indicate that the previously studied insulin-binding sites are the physiological macromolecular receptors for insulin.
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