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  • Title: Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin.
    Author: Segal R, Milo-Goldzweig I, Joffe AZ, Yagen B.
    Journal: Toxicol Appl Pharmacol; 1983 Sep 30; 70(3):343-9. PubMed ID: 6636168.
    Abstract:
    In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.
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