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  • Title: Monensin and the prevention of tryptophan-induced acute bovine pulmonary edema and emphysema.
    Author: Hammond AC, Carlson JR, Breeze RG.
    Journal: Science; 1978 Jul 14; 201(4351):153-5. PubMed ID: 663643.
    Abstract:
    3-Methylindole, a ruminal fermentation product of tryptophan, induces acute pulmonary edema and emphysema in cattle, and 3-methylindole is present in the ruminal fluid and blood of cows with a natually occurring form of this disease. Monensin, a polyether antibiotic and widely used feed additive for beef cattle, prevented tryptophan-induced acute bovine pulmonary edema and emphysema. Monensin acted by reducing the ruminal conversion of L-tryptophan to 3-methylindole both in vitro and in vivo. Lasalocid, also a polyether antibiotic, showed similar effects in vitro. These results provide a promising approach to prevention of this major respiratory disease of cattle.
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