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  • Title: [Lipid and apoprotein profile without and with oil load].
    Author: Herrmann W, Schütz C.
    Journal: Z Gesamte Inn Med; 1983 Aug 15; 38(16):437-41. PubMed ID: 6636909.
    Abstract:
    In 20 normolipaemic patients and 1 patient with hyperlipoproteinaemia (HLP type IV) the lipid profiles without and with oil load are taken (triglycerides, HDL-cholesterol, apolipoprotein A and B). For the oil load test at 7.00 a.m. 100 g sun-flower oil are given and then till 15.00 every two hours 2 ml venous blood are taken. The lipid profiles without oil load (in normal nutrition) take place in the same temporary course. Of the investigated parameters only the triglycerides show large and characteristic deviations in the profiles with oil load as well as in normal nutrition. For males (n = 10) in contrast to women (n = 10) larger variations in the TGL-profiles are found. According to the size of their TGL deviation the test persons can be divided into 4 groups (A to D), which at the same time possess clearly gradated HDLC levels. In group A (high HDL cholesterol) scarcely variations in the TGL profile (without and with oil load) are recognizable. Group D (relatively low HDL cholesterol) shows high peaks in the TGL curves (under oil load of more than 4 mmol/l). After a dietary and regadrin treatment of 6 months the HLP patient shows a remarkable improvement in the TGL and HDLC profile. The results are discussed from the point of view of the pathogenesis of arteriosclerosis and in this case particularly the role of the HDL cholesterol is concerned.
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