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  • Title: [Constrictive pericarditis: results and problems of conservative and surgical treatment].
    Author: Herrmann G, Gahl K, Simon R, Borst HG, Lichtlen PR.
    Journal: Z Kardiol; 1983 Sep; 72(9):504-13. PubMed ID: 6636933.
    Abstract:
    34 patients (pts.) with chronic constrictive pericarditis (CCP) were investigated by right and left heart catheterization and were followed at Hannover Medical School between 1975 and 1981. 12 pts. in NYHA stage II were treated medically (group I); 22 pts. (group II) in NYHA stages III or IV underwent surgery (pericardectomy). 7 pts. of group I and 12 pts. of group II underwent cardiac catheterization twice; the time interval between the two studies was at least 12 months, averaging 34 +/- 16 months in group I and 34 +/- 19 months in group II. 2 pts. of group I underwent pericardectomy after the second investigation. In group I the mortality was 16.7% (2 out of 12 pts.), both pts. being in stage IV. Hospital mortality in group II amounted to 20.8% (5 out of 24 pts.); late mortality was 4.2% (1 out of 24 pts.). However, 2 of 5 pts. who died in hospital had also undergone aortic and/or mitral valve replacement, and one was on chronic hemodialysis. Additional disorders of liver, lung, and/or kidney function or aortic and/or mitral valve replacement increased the operative risk considerably. Cardiac catheterization performed in 7 out of 12 pts. of group I yielded slight but significant hemodynamic deterioration under conservative management, and 2 of these pts. required surgery after reinvestigation. Cardiac catheterization performed postoperatively in 12 pts. of group II demonstrated normal hemodynamics, especially a decrease in right and left atrial and ventricular enddiastolic pressures (p less than 0.001) and an improvement in cardiac index (p less than 0.05) and stroke index (p less than 0.01). These observations suggest the following conclusions: Pts. in NYHA stage II can be treated medically as long as additional disorders are absent. Hemodynamic deterioration, however, is unpredictable, and approximately one third of pts. may deteriorate rapidly. Therefore, careful clinical observations and repeated hemodynamic studies are necessary. Pericardectomy is still associated with a rather high mortality, depending on additional disorders of liver, lung, and/or kidney function, which accumulate in pts. with long histories of right heart failure. On the other hand, late postoperative results are favorable. When the patient has liver, lung, and/or kidney damage or a long history of cardiac insufficiency, or is advanced in age, operation should be performed even in NYHA stage II because of the increasing operative risk attending higher stages of cardiac insufficiency.
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