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  • Title: Combined ulcerogenic effect of ethanol and acetylsalicylic acid on the gastric mucosa of the rat.
    Author: Hirvonen J, Huttunen P, Martimo KP, Puurunen J.
    Journal: Z Rechtsmed; 1983; 90(4):239-46. PubMed ID: 6637151.
    Abstract:
    The effect on rat gastric mucosa of ethanol and acetylsalicylic acid given at two doses singly or in combination were studied by administering the drugs into the stomach. 40% ethanol alone caused many ulcerations after 5 h, and the effect was even more marked with simultaneous administration of acetylsalicylic acid (ASA). 10% ethanol and 50 mg ASA/kg b. wt. were tolerated well. The mucosal lesions consisted of coagulation necrosis and hemorrhages, with a disappearance of histamine and serotonin from the mucosal mast cells in and around the lesion.
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