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  • Title: [Efficacy of doxorubicin (adriamycin) in disseminated forms of breast cancer].
    Author: Trofimova NB, Gorbunova VA.
    Journal: Antibiotiki; 1983 Aug; 28(8):625-8. PubMed ID: 6638976.
    Abstract:
    The efficacy of doxorubicin used alone or in combination with other drugs in chemotherapy of 53 patients with disseminated breast cancer was studied. Doxorubicin combinations with vincristine, cyclophosphamide, 5-fluorouracil and cyclophosphamide, 5-fluorouracil, cyclophosphamide and methotrexate were used. The efficacy of the treatment amounted to 35--50 per cent. Alopecia and hemopoiesis inhibition were the main adverse reactions. Over the past years a new combination of cyclophosphamide, doxorubicin (adriamycin) and cis-platinum was used in the treatment of 45 patients with disseminated breast cancer. The objective effect was observed in 14 patients (38.9 per cent). In 4 of them complete tumor regression was recorded. The administration regimens and side effects of the drugs are described.
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