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  • Title: Regulation of prolactin secretion in the pregnant pig: effect of fetal hypophysectomy and fetal death in small litters.
    Author: Kendall JZ, Richards GE, Frankowski RF.
    Journal: Biol Reprod; 1983 Sep; 29(2):412-21. PubMed ID: 6640027.
    Abstract:
    Fetal effects on prolactin secretion in late pregnancy and at term were studied in gilts with small litters of intact, hypophysectomized, partially hypophysectomized or dead fetuses. Litter size was reduced at surgery at Days 30-40 of gestation and fetal hypophysectomy or sham procedure attempted on Days 90-95 of gestation using an electrocoagulating probe. Plasma prolactin concentrations rose markedly before parturition in three gilts with normal litters (P = 0.05) and to lower peak concentrations in two gilts with a single fetus. Plasma prolactin did not change from basal concentrations in 4 gilts with small litters (1-2 fetuses) of hypophysectomized fetuses or, in 2 gilts with dead fetuses. Basal plasma prolactin concentrations were significantly lower in gilts carrying hypophysectomized or dead fetuses, compared to normal gilts (P = 0.01). A surge of prolactin secretion preceded delivery in 2 gilts with fetuses with incomplete hypophysectomy and in 1 gilt with 1 of 3 hypophysectomized fetuses. Abnormal patterns of prolactin secretion were seen in 1 gilt with 3 of 5 hypophysectomized fetuses and in 1 gilt with 1 partially hypophysectomized fetus. The results suggest that the fetus may be associated with a mechanism regulating plasma prolactin concentration at term. It is possible that this association may be by way of the fetal pituitary endocrine axes, and/or a function of conceptual mass.
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