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  • Title: [Enzyme activity of thiamine pyrophosphate in the rat after oxythiamine administration].
    Author: Strumilo SA, Senkevich SB, Galitskiĭ EA, Vinogradov VV.
    Journal: Biull Eksp Biol Med; 1983 Nov; 96(11):42-4. PubMed ID: 6640096.
    Abstract:
    Intraperitoneal injection of hydroxythiamine to rats (1 mmol per kg bw) resulted after 2-4 h in a more than 4-fold decrease in the activity of the oxoglutarate dehydrogenase complex, pyruvate dehydrogenase complex and NADP-dependent isocitrate dehydrogenase in adrenal mitochondria. Inhibition of hyaloplasmic transketolase, 6-phosphogluconate dehydrogenase and NADP-dependent malate dehydrogenase occurred later. Based on the correlation of the time course of enzymatic activity in the adrenals and the decreased concentration of 11-hydroxycorticosteroids in the blood the paramount role in the maintenance of the steroidogenesis among thiamine pyrophosphate-containing enzymes is assigned to the oxoglutarate dehydrogenase and pyruvate dehydrogenase complexes.
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