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  • Title: Single dose metronidazole with and without cefuroxime in elective colorectal surgery.
    Author: Mitchell NJ, Evans DS, Pollock D.
    Journal: Br J Surg; 1983 Nov; 70(11):668-9. PubMed ID: 6640241.
    Abstract:
    Seventy patients undergoing elective colorectal surgery for malignant and inflammatory bowel disease were allocated randomly to one of two groups. Patients in group 1 were given, after induction of anaesthesia, a single dose of metronidazole 500 mg i.v. Patients in group 2 were given in addition a single dose of cefuroxime 1.5 g i.v. Of 34 patients in group 1, 4 (11.8 per cent) developed postoperative infection. Of 36 patients in group 2, 5 (13.6 per cent) developed postoperative infection. No significant difference was noted in the incidence of postoperative sepsis between the two treatment groups.
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