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  • Title: [Characteristics of the intensity of glycolytic and oxidative processes in rat brain tissue under hypoxia and hyperoxia].
    Author: Podvigina TT, Troshikhin GV, Bogdanova TS.
    Journal: Ukr Biokhim Zh (1978); 1978; 50(2):155-9. PubMed ID: 664025.
    Abstract:
    Effect of hypoxia and hyperoxia on some indexes of energy metabolism was studied in the brain of intact rats and those with preliminarily administered hydrocortisone. So hypoxia (8 and 5.5% of oxygen in the medium) increases considerably the lactate and pyruvate content and has no effect on the oxidation and photophosphorylation in the brain mitochondria. The hyperoxic medium (1 at. abs. for 3-5h) inhibits consumption of oxygen and inorganic phosphate by the brain mitochondria, does not effect the lactate content and lowers the pyruvate level. The preliminary administration of hydrocortisone (1 mg per 100 g) under conditions of hypoxia and hyperoxia leads to the further intensification of the glycolysis independently of the initial level of the process. At the same time hormone administration favours normalization of the oxidative processes in the brain tissue under conditions of hyperoxia.
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