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  • Title: Aberrant de novo methylation of DNA after treatment of murine cells with N-acetoxy-N-2-acetylaminofluorene.
    Author: Boehm TL, Grunberger D, Drahovsky D.
    Journal: Cancer Res; 1983 Dec; 43(12 Pt 1):6066-71. PubMed ID: 6640548.
    Abstract:
    The ultimate chemical carcinogen N-acetoxy-N-2-acetylaminofluorene inhibits the enzymatic methylation of newly replicated DNA in cultured mouse P815 cells in a dose-dependent manner. After removal of the carcinogen, a significant de novo methylation of newly replicated DNA takes place, the level of methylation being higher than in control cultures. This aberrant methylation persists in the absence of N-acetoxy-N-2-acetylaminofluorene in subsequent cell cycles. Cellular cloning experiments suggest that N-acetoxy-N-2-acetylaminofluorene treatment leads to two distinct sets of cells, one with a higher and another with a lower extent of enzymatic methylation of DNA, contrasting to the apparent uniform methylation pattern in control clones.
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