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  • Title: Distribution of neurons with high-affinity uptake sites for GABA in the myenteric plexus of the guniea-pig, rat and chicken.
    Author: Saffrey MJ, Marcus N, Jessen KR, Burnstock G.
    Journal: Cell Tissue Res; 1983; 234(1):231-5. PubMed ID: 6640620.
    Abstract:
    The occurrence of neurons possessing high-affinity uptake sites for GABA was studied in the myenteric plexus of the guinea-pig ileum, caecum, and proximal and distal colon, the rat proximal colon, and the chicken gizzard with the use of 3H-GABA and autoradiography. Experiments were carried out on plexuses that had been freshly isolated from the gut wall or on isolated plexuses that had been maintained as explant cultures for 7 to 14 days. Scattered neurons selectively labelled with 3H-GABA were found in the myenteric plexuses from all the areas examined. The results suggest that GABAergic neurons are widely distributed in the enteric nervous system.
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