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  • Title: Urinary excretion of glycosaminoglycans, hydroxyproline and hydroxylysine in rabbits after excessive ingestion of fluoride.
    Author: Jha M, Koacher J, Susheela AK.
    Journal: Clin Exp Pharmacol Physiol; 1983; 10(5):615-9. PubMed ID: 6641020.
    Abstract:
    Urinary levels of glycosaminoglycans (GAG) and hydroxyproline from normal and fluoride treated rabbits were estimated. The hydroxylysine content of serum and urine of rabbits after excessive ingestion of fluoride was also investigated. There was a progressive decrease in GAG content, reduction in hydroxylysine, whereas the hydroxyproline content was increased after fluoride ingestion. Enhanced hydroxyproline in urinary excretion is due to collagen breakdown after fluoride ingestion. The reduction in hydroxylysine content is due to reduced collagen cross-link formation. The report suggests the possibility of using the urinary levels of GAG or hydroxyproline or hydroxylysine as an index of fluoride intoxication.
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