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  • Title: Membrane potential in smooth muscle cells from hypertrophic rat portal vein.
    Author: Sigurdsson SB, Uvelius B.
    Journal: Experientia; 1983 Nov 15; 39(11):1288-90. PubMed ID: 6641906.
    Abstract:
    Portal hypertension was induced in rats by partial ligation of the hepatic branches of the portal vein. After 5 days the vein was removed and mounted in vitro. In contrast to control (C) veins, hypertensive (H) vessels were almost devoid of spontaneous contractions. Microelectrode recordings showed that the smooth muscle cells of H vessels were hyperpolarized. If [K+]o was increased, or if Ba2+ was added spontaneous activity could be initiated in H vessels. A relation in H cells between hyperpolarization and increased aerobic glycolysis (suggesting an increased electrogenic Na+-K+-pumping) is proposed.
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