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  • Title: Pyrrolnitrin analogues. VIII - Synthesis and antibacterial activity of new 1,4- and 1,5-diarylpyrroles.
    Author: Filacchioni G, Porretta GC, Scalzo M, Giardina MC, Giardi T.
    Journal: Farmaco Sci; 1983 Sep; 38(9):630-9. PubMed ID: 6641928.
    Abstract:
    From ethyl 1-aryl-2-methyl-4-(4-nitrophenyl)pyrrole-3-carboxylates new 1-aryl-2-methyl-4-(4-nitrophenyl)pyrrolderivatives wer prepared. These compounds and some previously reported 1,4- and 1,5-diarylpyrroles were subjected to in vitro antimicrobial screenings. Namely some 1-aryl-2-methyl-4-(4-nitrophenyl)pyrrole-3-carboxylic acids and its 5-chloroderivatives are the most potent. The results obtained are discussed on the basis of structure-activity relationships.
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