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  • Title: Derivatives of 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity. I.
    Author: Mariani E, Bondavalli F, Schenone P, Ranise A, Vacca C, Chieppa S, Spadaro R, Marmo E.
    Journal: Farmaco Sci; 1983 Sep; 38(9):653-63. PubMed ID: 6641931.
    Abstract:
    The synthesis of three series of glycinamides (IV), amides (V) and diamines (VI) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of compounds (IV), (V) and (VI) showed a moderate hypotensive activity in rats. Effects on heart rate in rats, infiltration anesthesia and antiarrhythmic activity in mice, as well as antiacetylcholine activity in vitro, are also reported.
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