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  • Title: [Aryl esters of N-benzyldithiocarbamic acid with antimycotic activity].
    Author: Mazza M, Pavanetto F, Montanari L, Modena T.
    Journal: Farmaco Sci; 1983 Sep; 38(9):709-12. PubMed ID: 6641936.
    Abstract:
    Some aryl esters of N-benzyldithiocarbamic acid [substances (I leads to XVI)], in which S aryl substituents were hydrophylic or potentially hydrophylic groups, were tested for in vitro antifungal activity against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results, given in Table I, show the marked activity as antifungal agents of the N-benzyldithiocarbamic acid aryl esters studied; the antifungal activity, connected with the N-benzyldithiocarbamic group, is only slightly influenced by the nature of the substituents.
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