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  • Title: The effect of S-100a and S-100b proteins and Zn2+ on the assembly of brain microtubule proteins in vitro.
    Author: Deinum J, Baudier J, Briving C, Rosengren L, Wallin M, Gerard D, Haglid K.
    Journal: FEBS Lett; 1983 Nov 14; 163(2):287-91. PubMed ID: 6641944.
    Abstract:
    The homologous proteins S-100a and S-100b affect the microtubule system in a distinctly different way in the presence of low molar ratios of Zn2+. Assembly of brain microtubule proteins can be almost completely inhibited and rapid disassembly can be induced by low molar amounts of S-100b in the presence of low molar ratios [2-4] of Zn2+. Higher molar ratios per S-100b (greater than 4) potentiate the general Zn2+ effect, promoting the formation of sheets of microtubules. However, the effect of S-100a is quite different, no inhibition of assembly can be observed and the presence of S-100a seems to protect the microtubule proteins against the effect of Zn2+ by chelating the Zn2+ and decreasing the free metal-ion concentration. S-100a or S-100b cannot bind to the microtubule polymer-form, either in the absence or in the presence of Zn2+.
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