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  • Title: Studies on the antigenic composition of aqueous cotton dust extracts.
    Author: O'Neil CE, Reed MA, Aukrust L, Butcher BT.
    Journal: Int Arch Allergy Appl Immunol; 1983; 72(4):294-8. PubMed ID: 6642705.
    Abstract:
    An immune response to cotton dust components has been proposed as a possible mechanism of byssinosis. To evaluate this possibility, specific precipitating antibodies against aqueous cotton dust extracts (ACDE) were raised in rabbits, and a reference pattern for crossed immunoelectrophoresis (CIE) was established using this extract. A significant portion of the immune response was directed against Alternaria tenuis, Aspergillus niger, and Fusarium solani, all documented contaminants of cotton dust. Preliminary crossed radio-immunoelectrophoretic studies demonstrated that some of these antigens are allergenic in man, suggesting that an IgE-mediated hypersensitivity against cotton dust, or a fungal component of the dust, may be important in byssinosis pathogenesis.
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