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  • Title: 26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture.
    Author: Esterman AL, Baum H, Javitt NB, Darlington GJ.
    Journal: J Lipid Res; 1983 Oct; 24(10):1304-9. PubMed ID: 6644180.
    Abstract:
    The effect of 26-hydroxycholesterol and other intermediates in bile acid synthesis on HMG-CoA reductase activity was studied in Chinese hamster ovary (CHO) cell culture. Incubation of CHO cells for 5 hr in 0.25 microM 26-hydroxycholesterol caused a 40% inhibition of HMG-CoA reductase activity. All other intermediates tested including 3 beta-hydroxy-5-cholenoic acid and cholest-5-ene-3 beta,7 alpha,26-triol, oxidation products of 26-hydroxycholesterol, had little or no inhibitory effect. It is proposed that 26-hydroxycholesterol has a selective biological role in the regulation of cholesterol synthesis.
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