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  • Title: Mechanism of epithelial lithium transport. Evidence for basolateral Na:Na and Na:Li exchange.
    Author: Kirk KL, Dawson DC.
    Journal: J Gen Physiol; 1983 Oct; 82(4):497-510. PubMed ID: 6644269.
    Abstract:
    Measurement of transmural sodium fluxes across isolated, ouabain-inhibited turtle colon in the presence of a serosal-to-mucosal sodium gradient shows that in the absence of active transport the amiloride-sensitive cellular path contains at least two routes for the transmural movement of sodium and lithium, one a conductive path and the other a nonconductive, cation-exchange mechanism. The latter transport element can exchange lithium for sodium, and the countertransport of these two cations provides a mechanistic basis for the ability of tight epithelia to actively absorb lithium despite the low affinity of the basolateral Na/K-ATPase for this cation.
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