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  • Title: Effect of electroconvulsive shock on muscarinic cholinergic receptors in rat cerebral cortex and hippocampus.
    Author: Lerer B, Stanley M, Demetriou S, Gershon S.
    Journal: J Neurochem; 1983 Dec; 41(6):1680-3. PubMed ID: 6644306.
    Abstract:
    Single electroconvulsive shock (ECS) induced no change in [3H]quinuclidinyl benzilate ([3H]QNB) binding to muscarinic cholinergic receptors in rat cortex and hippocampus. ECS administered once daily for 7 days induced a significant reduction in [3H]QNB binding in both brain areas. Concurrent ECS reversed the significant increase in cortical [3H]QNB binding induced by chronic atropine administration. These findings may have relevance to the antidepressant or amnestic effects of electroconvulsive therapy.
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