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  • Title: [State of the skin and underlying tissues in late periods following the radiation therapy of lymphogranulomatosis].
    Author: Shishkin IP.
    Journal: Med Radiol (Mosk); 1983 Nov; 28(11):12-5. PubMed ID: 6645823.
    Abstract:
    A study was made of 200 patients with Hodgkin's disease in a prolonged remission (5-12 yrs.) resulting from radiation therapy. In a long-term period after treatment the patients' height and body mass usually correspond to those obtained at examination of the entire population. Late radiation fibrosis of the soft tissues was noted in 26 patients. It was caused by repeated irradiation for recurrences of Hodgkin's disease, excess single focal doses prior to surgical intervention in the zone of irradiation. In some cases (0.9%) while using wide irradiation fields late radiation fibrosis is also observed when radiation exposure did not exceed values that are considered normal for the treatment of patients with Hodgkin's disease. In some of the patients (at the moment of treatment their age ranged between 14-16) at later time pronounced hypotrophy of the neck soft tissues (the "thin neck" syndrome) was observed, accompanied by weakness, boring pain, convulsive muscular twitching in this area, causing cosmetic discomfort.
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