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  • Title: Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites.
    Author: Keyzer JJ, de Monchy JG, van Doormaal JJ, van Voorst Vader PC.
    Journal: N Engl J Med; 1983 Dec 29; 309(26):1603-5. PubMed ID: 6646186.
    Abstract:
    In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.
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