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  • Title: The preoperative use of cimetidine as a means of preventing symptomatic hypocalcemia following a parathyroid operation.
    Author: Sherwood JK, Ackroyd FW, Garcia M, Willis IH, Minervini D, Seiden EF.
    Journal: Surg Gynecol Obstet; 1983 Dec; 157(6):557-68. PubMed ID: 6648778.
    Abstract:
    Cimetidine has been shown to lower circulating PTH levels effectively by causing an intraglandular rearrangement of PTH peptides in human parathyroid tissue in instances of primary hyperparathyroidism. A state of "euparathyroidism" is established. It has been statistically found at a 98.7 per cent confidence level that preoperative treatment with cimetidine effectively prevents symptomatic hypocalcemia postoperatively after parathyroid operations. It is anticipated that cimetidine has provided a tool for the in depth exploration of parathyroid disease.
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