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  • Title: Protection of cattle against Theileria annulata infection using Corynebacterium parvum.
    Author: Manickam R, Dhar S, Singh RP.
    Journal: Trop Anim Health Prod; 1983 Nov; 15(4):209-13. PubMed ID: 6649060.
    Abstract:
    Four groups of calves (A, B, C and D) each consisting of five calves were used for the present study. Group A calves were given Corynebacterium parvum alone. Group B calves were inoculated with inactivated ground-up-tick supernate (GUTS) prepared from Hyalomma anatolicum anatolicum infected with Theileria annulata plus C. parvum. Group C received only inactivated GUTS. All the surviving calves of groups A to C were exposed on day 45 post-inoculation to a lethal tick challenge along with susceptible control calves of group D. All the calves of groups A and B withstood the challenge whereas all the calves of groups C and D died of theileriosis. Complement fixing antibodies were detected in calves of groups B and C. A significant decrease in neutrophils and a significant increase in monocytes was observed in calves of groups A and B. No significant changes were seen in other cell types. The results of this study demonstrated that C. parvum alone may be used as an immunostimulant for producing non-specific resistance against T. annulata.
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