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  • Title: [Mechanism of retardation of fibrin polymerization using a thermostable inhibitor from human serum].
    Author: Byshevskiĭ ASh, Chiriat'ev EA.
    Journal: Vopr Med Khim; 1983; 29(5):22-7. PubMed ID: 6649529.
    Abstract:
    A purified thermostable inhibitor of fibrin polymerization was found to have a molecular mass of 1,750 +/- 100 daltons. Early steps of the fibrin polymerization were the most sensitive to the effect of this inhibitor; less distinct but constant activity was exhibited by the inhibitor at later steps of the process. As shown by kinetics of inhibition the inhibitor reacted with fibrin-monomer as well as with more complex products of polymerization but the final products (unstabilized fibrin) did not contain this substance. The inhibitor was found in a number of tissues. The inhibitor appears to be responsible for long-term existence of fibrin-monomer in circulation.
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