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  • Title: [Effect of the use of lidocaine on patients with acute myocardial infarct].
    Author: Beloev I, Tomov I, Dzhonov A, Orbetsov M, Stankusheva G.
    Journal: Vutr Boles; 1983; 22(3):88-95. PubMed ID: 6649590.
    Abstract:
    In 411 patients with acute myocardial infarction (AMI) the effect of intravenous lidocaineeee administration was studied in a suboptimal dose - under 1,5 mg/min (to 1979) and in the optimal dose - over 1,5 mg/min, minimum 2 mg/min during the first 12 hours, with an average 24 h dose, 3,0 g in the course of 48 hours. The patients were grouped into three prognostic groups, depending on their initial assessment according to the coronaryprognostic index of M. R. Norris (1969). The indices, via which the drug effect was determined; were 13, the more significant ones beind: ventricular arrhythmias, early lethality rate, postinfarction angina pectoris and regression fo lesion-ischemic ST-T alterations. It was established, after the analysis of the data obtained, that the prophylactic and therapeutic use of lidocain, considerably reduced the incidence of ventricular arrhythmias in patients with AMI. Lidocain, in an optimal dose, reduces the incidence, justifying its routine administration. Lidocain effect on ventricular arrhythmias, the early lethality rate and certain complications (postinfarction angina pectoris, early cardiac insufficiency, regression of ST-T alterations) in AMI, depend on the initial prognosis and the stage of the hemodynamic disorders.
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